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Masella, A

Microsomal mono-oxygenase system An enzymatic system located in microsomes that depends on cytochrome P450s, and metabolizes drugs, xenobiotics (including toxins and carcinogens) and some intermediary metabolites, detoxifies them and makes them more hydrophilic

By 1963, when the Surgeon Generals advisory committee was reviewing the worlds literature on smoking, there were 7,000 articles in scientific journals

The critical importance of microorganisms residing on tobacco leaf surfaces in enhancing tobacco quality throughout the curing stage has been highlighted by recent discoveries

However, some people on Miyako Island have begun taking up tobacco farming in their early 20s, giving Sunagawa a lot of hope for the future