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Created and pitched by former professional baseball players as a healthy and sweet alternative to chewing tobacco

Int J Res Pharm Sci 12(3):20882094 Das A, Bhattacharya A, Chakrabarty S, Ganguli A, Chakrabarti G (2013) Smokeless tobacco extract (STE)-induced toxicity in mammalian cells is mediated by the disruption of cellular microtubule network: a key mechanism of cytotoxicity
therefore, its findings can be applied to real cases

Over time, bone loss can occur, eventually requiring surgical intervention to repair any damage