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Determine the effect of progressive nicotine content reduction on nicotine metabolites and other biomarkers of smoking exposure

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[16] The harmful effects of carbon monoxide are generally considered to be due to tightly binding with the prosthetic heme moiety of hemoproteins that results in interference with cellular operations, for example: carbon monoxide binds with hemoglobin to form carboxyhemoglobin which affects gas exchange and cellular respiration

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