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For instance, in his ground-breaking paper on Brownian movement, explaining the patterns of movement of tiny particles in gases or liquids, the dance of pipe smoke was used as the example cementing the existence of atoms and molecules

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aureus develops a defense phenotype biofilm by altering gene expression, which results in the bacteria becoming embedded in a protective biofilm that renders them less susceptible to eradication

These findings indicate that environmental exposure, such as exposure to cigarette smoke, modulates disease risk and progression through intricate interactions with genetic factors such as GPR15, thereby influencing disease susceptibility and phenotype