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Although IV is frequently associated with atopic dermatitis, only half of the patients with this inflammatory disease associate pathogenic variants in FLG.13 IV is caused by semi-dominant pathogenic variants in FLG14a gene encoding the filaggrin proteinthe major protein inside corneocytes

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Some of the signs of gum disease include: Bleeding gums when you brush your teeth however, smoking causes constriction of your blood vessels which might mask the signs of bleeding

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