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Moreover, the following exclusions were also made: cardiovascular diseases, diabetes, hepatobiliary disease, hematological abnormalities, respiratory diseases, neurological diseases, patients with endocrine disease, excessive alcohol intake or drug abuse history, those who were positive for HIV-I, had abnormal laboratory values, any prior surgery of the gastrointestinal tract that might interfere with the drug absorption, treatment with any known hepatic enzyme-inducing/inhibiting agents within 30 days prior to the start of the study and throughout the study, treatment with any known CYP3A4 inhibitor or inducer drug, those who had been administered any medication less than two weeks before the study start date and any subjects who had donated blood or who participated in clinical studies that required multiple blood sample collections within the 1.5 months prior to the study start date