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The level of cellular p53 protein is subjected to a wide range of post-translational modifications by which its subcellular localization, stability, and conformation can be regulated 15,16
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Due to the structural similarity of beta-lactams with the terminal D-Ala-D-Ala of the pentapeptide precursor, which is the natural substrate of PBPs, these antibiotics form a stable acyl-enzyme covalent bond with PBPs abolishing their peptidoglycan cross-linking activity (Sauvage et al., 2008)

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Background paper on E-cigarettes (electronic nicotine delivery systems).Center for Tobacco Control Research and Education, University of California, San Francisco, a WHO Collaborating Center on Tobacco Control