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Additionally, it protects them from damage while in transit

These toxic substances are then filtered by the kidneys and become concentrated in the urine, which exposes the lining of the bladderthe urotheliumto prolonged contact with these harmful agents

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The present study, as part of the Global Burden of Diseases, Risk Factors, and Injuries Study (GBD) 2020, re-estimated the continuous doseresponse relationships (the mean risk functions and associated uncertainty estimates) between current smoking and 36 health outcomes (Supplementary Table 1) by identifying input studies using a systematic review approach and employing a meta-analytic method 28