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Much of that uncertainty comes from two major issues: cannabis has historically been illegal in many countries, limiting high-quality prospective research, and most people who smoke cannabis also smoke tobacco, making it difficult to separate the effects of one exposure from the other
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This interference is yet another reason why smoking can have detrimental effects on the body's detoxification process
We therefore adjusted for this by multiplying the F AA by the frequency of alcohol-consumers who are never-smokers (53%), and the F TA by the frequency of smokers who do not consume alcohol (12%), for cancers in which both alcohol and tobacco are known risk factors (Additional file 1: Table S2)
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