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Description
The fact that numerous attempts in this direction have been made, and yet thee is no substitute for tobacco and no de-nicotinized tobacco in general use, is itself a sufficient answer to the question
Control 2007, 16 (2), 113
[91] When nicotine intake stops, the upregulated nicotinic acetylcholine receptors induce withdrawal symptoms
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In the U.S., rates of vaping are higher among youth than older adults
