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The goal of nicotine replacement therapy is to gradually reduce the desire to smoke, help reduce withdrawal symptoms from quitting, and undermine the triggers that make it difficult to quit

In a 6-month clinical study in the USA, smokers who switched from smoking cigarettes to predominant THS use showed significant improvements in clinical risk endpoints associated with O 2 delivery (decreased carboxyhaemoglobin levels), inflammation (reduced white blood cell count), and COPD (increased FEV 1 ), although their plasma nicotine levels remained similar to that in smokers

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doi: 10.1038/nrmicro2746 96 KumarG

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