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And so, of all the original brands - cigarettes with the names of local rivers, only "Drina" remained, the amount of nicotine, for which tobacco is normally smoked, was halved in just 10 years, and if it were to be compared with that from the golden age, it was reduced to a third

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Achieving this can be challenging and great care has to be given when choosing exposure dose ranges, which can be based on (i) animal to human exposure conversion factors for in vivo studies [82] and (ii) human data for in vitro studies [83, 84]