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Smoking is one of the leading causes of preventable deaths worldwide, and it has been linked to numerous health problems, such as lung cancer, heart disease, stroke, and respiratory diseases

PMID: 171

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In addition to being at a higher risk of suicide, individuals with LLD are often unresponsive to traditional antidepressants

These fibers primarily mediate non-histaminergic itch by responding to exogenous stimuli or activating immune cells such as MCs, thereby inducing both acute and chronic pruritic responses and contributing to neuroimmune interactions within the AD microenvironment (88)