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by Thomas Nast, in Charles Dickens's Passage Illustrated: Dickens's Disgust at American Chewing and Spitting of Tobacco As Washington may be called the head-quarters of tobacco-tinctured saliva, the time is come when I must confess, without any disguise, that the prevalence of those two odious practices of chewing and expectorating began about this time to be anything but agreeable, and soon became most offensive and sickening

Journal of stomatology, oral and maxillofacial surgery , 119 (5), 407-411

Nicotine is a major pharmacological agent in cigarette smoke

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The use of snus has also been associated with obesity in a cross-sectional analysis of controls in a case-control study [13]