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Nicotine, in addition, up-regulates LPS-mediated monocyte secretion of PGE2 and IL-1B

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Students who used either cannabis or tobacco, but not both, also had slightly lower grades than nonusers: students who only used tobacco had an average grade of 5.61 (mostly Bs), and students who only used cannabis had an average grade of 5.54 (mostly Bs)

A similar pattern is shown by trends in 30-day prevalence (current smoking) among high school youth (see Figure 1-7 for the 12th grade data)

For more details on the citys strategy and lessons learned, review Reducing Tobacco Retail Density in San Francisco: A Case Study