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FDA regulations of e-cigarettes began in 2016 with the deeming rule determination that the sale and distribution of e-cigarette products fall under the agencys current authority [74]

From there, the meme just took off, predominantly peaking in usage in mid-2019

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The FDA will begin to look at lowering the nicotine content of combustible tobacco products and will be seeking public input on the potential public health benefits and any possible adverse effects of lowering the nicotine content of combustible cigarettes