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Plants produce an average of 20 leaves per plant with a nicotine content of 1%
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[22] The smoking of tobacco and various hallucinogenic drugs was used to achieve trances and to come into contact with the spirit world
One practical consideration: nicotine replacement therapy (patches, gum, lozenges) can produce positive cotinine results even after cigarette cessation meaning a former smoker using NRT to quit may still test positive for cotinine and be classified as a tobacco user at carriers that treat any positive cotinine as smoker-equivalent
