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The use of tobacco is known to have long-term negative effects on olfactory function due to changes in the olfactory nerve (the nerve that provides a sense of smell) epithelium and increased apoptosis of the olfactory neurons

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In addition, effects of smoking cessation on endothelial function may differ by sex, age, and risk severity of the subject

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[7] [1] The measure requires funds in the preschool programs cash fund to be used to expand and enhance the Colorado Preschool Program (CPP) in order to provide at least 10 hours per week of preschool to every Colorado child free of charge during the child's last year of preschool before beginning kindergarten