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The addition of the longitudinal element to the analysis, allowing capture of recent changes in smoking history and hot flash symptoms, increases the sensitivity of the study

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Quality of evidence and strengths of recommendations The quality of evidence and strength of a recommendation were assessed based on the Minds Manual for Guideline Development 2017 [1] and GRADE System for Clinical Practice Guideline, Third Edition [2]

Common side effects include gastrointestinal issues or cardiovascular effects when misused

Once again, this prevents combustion from happening, and as a result, heat-not-burn products have the same difference from cigarettes as e-cigarettes of being smoke-free