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Nature 526:212217 Royal W III, Can A, Gould TD, Guo M, Huse J, Jackson M, Davis H, Bryant J (2018) Cigarette smoke and nicotine effects on brain proinflammatory responses and behavioral and motor function in HIV-1 transgenic rats
(2019) 9, no

Zheng T, Zhang Q, Li P, Wu X, Liu Y, Yang Z, Li D, Zhang J, Du G (2022) Analysis of microbial community, volatile flavor compounds, and flavor of cigar tobacco leaves from different regions
Among these, the most significant impact is for I471T (CYP2A67) and V365M (CYP2A617), which have decreased intrinsic clearance of 83% and 69%, respectively (125, 126, 127, 128)
and more community leaders have started speaking publicly about quitting, along with other healthy lifestyle choices
