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When tested in the lungs, DNA methylation correlated inversely with the levels of AHRR mRNA in both smokers and non-smokers ( AHRR encodes a transcription factor that inhibits the aryl hydrocarbon receptor pathway, which enhances the expression of detoxification (xenobiotic-metabolizing) enzymes of environmental pollutants, such as polycyclic aromatic hydrocarbons contained in cigarette smoke ( AHRR DNA methylation and related increases in AHRR expression may compromise the bodys capacity to metabolize and thus remove harmful environmental chemicals, and as such may represent a potential mechanism of increased risk of carcinogenesis in smokers