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Interestingly, phosphorylation of mutp53 on Ser15/Ser37 by DNA-PK favors stabilization of mutp53 and enhances its gain-of-function activity in ovarian cancer [47]
The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are strongly associated with metabolic syndrome, both of which are the independent risk factors for HCC development 111
doi: 10.1016/j.jsbmb.2014.11.015
doi: 10.1091/mbc.e07-10-1041
