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Tobacco has been very present throughout history, no less than since its appearance in the Andean highlands between 2,500-3,000 years B.C, the first cultures of the Incas 2,000 years B.C

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Effect of Health Status, Smokeless Tobacco Consumption, and Sampling Sites on Oral Microbiome Composition Different indexes (Shannon, Simpson, and Chao 1) were employed to estimate the -diversity of the bacterial community in different groups of samples ( Supplementary Figure S1 )

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