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have active problem substance use (other than nicotine) severe enough to compromise ability to safely participate in the study protocol, in the investigators opinion

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This can be connected to greening out, which is when someone feels sick or anxious after using too much cannabis

It has flooded the U.S

Federal Not applicable under Federal law State Retail tobacco and vapor product licensees must post a sign (provided free of charge by the Liquor and Cannabis Board) that is clearly visible to anyone purchasing restricted products that says: THE SALE OF TOBACCO OR VAPOR PRODUCTS TO PERSONS UNDER AGE 21 IS STRICTLY PROHIBITED BY STATE LAW