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"Bar shuts as smoking rebel loses court fight"

Keywords: Addiction, Electronic nicotine delivery devices, Nicotine, Tobacco industry documents Introduction Tobacco dependence is understood to be a complex process that is primarily caused by the pharmacological effects of nicotine which activate nicotinic acetylcholine receptors in the brain leading to release of the neurotransmitter dopamine into the mesolimbic area, corpus striatum and frontal cortex

(PRATCO) in 1912
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29) Further reading [edit] Clemants, Steve and Gracie, Carol Wildflowers in the Field and Forest: A Field Guide to the Northeastern United States Oxford University Press 2006
