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For all types of RNA viruses [(+)ssRNA, (-)ssRNA, dsRNA], 21-nt and 22-nt small RNAs are produced from both strands of the viral genome without any strong bias in most cases (Supplementary Table S1 and references therein), suggesting that those small RNAs are bona fide siRNAs processed by DCL4 and DCL2 from perfect dsRNA precursors in the form of 21-nt and 22-nt duplexes, respectively
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