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Future prospective studies with substantial number of non-smoker cases are needed to understand the influence of gender, and smoking status, on such associations

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Exposure to ecig aerosol and ejuice has been shown to cause a wide variety of biological changes in the airway including increased production and decreased clearance of mucin, 155 , 156 , 157 reduction in ciliary function, 157 , 158 increase in cytokines, 153 and impaired immune cell function

In step 5, in addition to generating funnel plots and visually inspecting for asymmetry (Figs

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