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1a and 1b, with some small quantitative differences as summarized in Fig
Although it is commonly thought that chewing is not as harmful, like the others, it contains nicotine and cancer-causing chemicals, and can also cause other health problems

Chest 1996
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Future investigations should integrate longitudinal human cohorts with mechanistic animal studies colonized by smoker-derived microbiota, which may provide causal insight into how specific taxa or metabolites mediate disease trajectories
