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Yu Y, Hu J, Wang PP, Zou Y, Qi Y, Zhao P et al (1997) Risk factors for bladder cancer: a casecontrol study in Northeast China

He added that for the proposal to have maximum impact, the FDA should reduce nicotine levels in all combustible tobacco products, not just cigarettes

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doi: 10.1007/s00213-007-0786-z

It is the complexity of tobacco carcinogenesis due to the presence of multiple carcinogens and toxicants however which continues to challenge investigators to identify specific mechanisms that fully explain the ways in which smoking causes lung cancer
