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Total Particulate Matter (TPM) was calculated as per ISO 3308 by weighing the holders before and after the smoking run 13

Nevertheless, the mechanisms of nicotine addiction remain only partially understood

Nicotine-only products [edit] Nicotine-only products are, like HTPs, a category of tobacco product which, except in the case of nicotine replacement therapy (NRT) products, were developed only somewhat recently

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Chronic use can increase the workload on the heart and contribute to arterial stiffness, potentially raising the risk of hypertension or cardiac events in susceptible individuals