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It essentially means that upon making attempts to stop, one experiences physical and mood-related symptoms, such as anxiety, strong cravings, irritability, lack of concentration, restlessness, depressed mood, rage, frustration, increased hunger, insomnia, constipation, or diarrhea

Abstract Studies were done to evaluate the lower oesophageal sphincter function of chronic smokers compared with non-smokers and to ascertain the acute effects of smoking on the sphincter and the occurrence of acid reflux

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88:622626 Ahmadnia H, Ghanbari M, Moradi MR, Khaje-Dalouee M (2009) Effect of cigarette smoke on spermatogenesis in rats

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