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Over the course of the next several weeks, Leppanen said, she pushed her colleagues to consider possible health and environmental risks from the pouch material

Later, and thanks to Doctor Nicols Monardes who published Historia medicinal de las cosas que se traen de la Nueva Espaa (1695) and Doctor Jean Nicot, French ambassador in Portugal and physician at the court of King Henry II of France, its medicinal value, and soon enough its commercial one, were subsequently discovered, popularizing it and causing its global distribution