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Nicotine and its preparations in concentrations of 10% or more are designated as poisons under the Poisonous and Deleterious Substances Control Act in Japan.[xvii] Even lower concentrations of nicotine are regulated under the Pharmaceutical and Medical Device Act, and vaping devices themselves are subject to the same Act.[xviii] This means they require approval before they can be manufactured and sold, but to date, no nicotine liquids or vaping devices have been approved for sale in Japan

Mix a small amount with water to form a paste, then brush gently for about two minutes

Other medications may be administered to manage blood pressure, heart rate and seizures

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