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Its farmers and their families are exposed to serious health risks through nicotine absorbed through the skin when handling wet tobacco leaves, exposure to heavy use of pesticides and to tobacco dust

New York Times , "Henry Hull in 'Tobacco Road'", December 5, 1933, p.31 Frank, Leah."Shocks Dissipated In 'Tobacco Road' " New York Times , October 13, 1985 Schildcrout, p

Additionally, nicotine has been shown to have a more pronounced impact on the brains reward pathways, contributing to its addictive nature

Furthermore, tobacco smoke induced lower airway dysbiosis in COPD, enriching oral commensals and promoting inflammatory pathways involving IL-17, IL-6, ERK/MAPK, and PI3K

Immune suppression with triamcinolone can be used to solve this issue