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19 A 10% increase in metabolic rate, corresponding to an expenditure of 200 kcal per 24 h, seems small

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Since the highest tar-and-nicotine content is to be found, generally speaking, in the best-selling brands of cigarettes, a good argument can be made for federal health regulations that would require systematic further reductions of the tar-and-nicotine content of all cigarettes over, say, a ten-year period