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As I mentioned, these are the fight-or-flight hormones that create the stress response listed in Illustration 1

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By promoting mitochondrial fusion and reducing fragmentation, Mdivi-1 has demonstrated protective effects against cell death and mitochondrial dysfunction in models of ALI and pulmonary fibrosis ( 8.1.3 Metformin and other metabolic modulators Metformin, primarily known as an anti-diabetic medication, has been found to inhibit mitochondrial ATP and DNA synthesis, which can abrogate NLRP3 inflammasome activation and reduce pulmonary inflammation