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Long-Term Effects of Nicotine Use Variations between the immediate and delayed response of the digestive system towards cigarette smoking over short-term or long-term periods are: Short-term effects of nicotine During this period users may observe a sudden alteration in their bowel habits including an increase in frequency accompanied by loose consistency, commonly known as diarrhea

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Journal of biological chemistry

PMID: 26389650 pubmed.ncbi.nlm.nih.gov/26389650/

Second generation e-cigarettes are reusable and introduce a refillable tank granting the user a better adjustment of nicotine exposure through the consumption of e-liquids containing variable nicotine concentrations [9]