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TAMs are mainly derived from macrophages that are recruited by cytokines, which are secreted by BC cells and cancer-infiltrated macrophages

Therefore the impact of recent interventions could alter the expected endpoint shown in the projection

However, the banning of flavours would be a de facto ban, which would discourage smokers looking to switch away

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Our working theory is that the underlying demand for the recreational drug nicotine is robust and its rewards potentially dependence-forming