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Users behaviour, such as length of puffs, depth of inhalation, and frequency of use, may also affect how vapours are consumed by the user. It has also been observed that a few metals like nickel and cadmium are used in e-cigarettes

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Microsomal prostaglandin E synthetase-1 gene (mPGES-1) and the PGE2 produced in the spleen are the key factors connecting the immune and nervous systems affected by nicotine (Revathikumar et al., 2018)

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