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Statistical comparisons were made using either Students t -test, one-way ANOVA, or two-way ANOVA as appropriate, followed by Bonferroni post hoc multiple comparisons test using GraphPad Prism version 8.0.0 for Windows (GraphPad Software, San Diego, CA)

This had mixed results but did show a slightly better chance of quitting when pre-loading

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Feeling the urge to poop (or fully experiencing diarrhea) after using nicotine is par for the course

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