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10.1016/S0893-133X(01)00296-2 37

This is difficult as the actual externalities are hard to estimate for any product, and no study on the subject exists for marijuana.[63] Not only is it hard to estimate cost related to marijuana use, but external cost is also impacted by substitution

When mitochondria are damaged, ROS (reactive oxygen species) production increases
Cigarette smoking induces small airway epithelial epigenetic changes with corresponding modulation of gene expression

however, these flavours will not always be to everyone's taste
