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This supports the role of the parthanatos pathway in protecting the organism against genomic mutations from exposure to increased toxin levels

Interestingly, mitochondria have their own genome (mitochondrial DNA (mtDNA)) and mtDNA gene expression changes have been identified in smokers: a comparative analysis showed that 32 out of 37 mitochondrial genes were upregulated in smokers with normal lung function, nine of which were shared in vapers, indicating an important involvement of mitochondrial genes in the cellular response to smoking [33]

Chen, H., Li, Z., Dong, L., Wu, Y., Shen, H., & Chen, Z

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While tobacco smoke is a known carcinogen, little is known about the health effects of the particles that are left in the air after you can no longer see the smoke