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The nicotine itself carries its own risks (cardiovascular, dependence), but the harm profile of pouches is substantially lower than cigarettes

Liu Q, Xu WG, Luo Y, Han FF, Yao XH, Yang TY, et al

The renaissance of male infertility management in the golden age of andrology

Long-term smokers often develop deep staining that can only be addressed with advanced whitening or cosmetic dentistry

In addition to directly activating p53, the excessive UVR-induced ROS activate JNK and p38 MAPK, which mediate p53 activation with upregulation of target genes exhibiting a pro-oxidant role such as BAX , the tumor protein p53 inducible protein 3 ( TP53I3 or PIG3 ), PUMA , and PMAIP1 (encoding NOXA) [60]