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Leukoplakia is a clinical diagnosis, but a biopsy is needed for a definitive diagnosis [44]

However, a doctor may suggest using nicotine patches alongside this drug

Various systematic reviews and longitudinal studies reported strong associations between EC use and the subsequent smoking behavior, whereby youths and adolescents who use EC have more than two times increased intention to cigarette smoking in the future than those who do not use EC [2, 17]

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