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The disruption of protein synthesis results in the production of non-functional or toxic peptides, leading to bacterial cell death ( Amikacin exerts bactericidal effects against both Gram-positive and Gram-negative bacteria, including strains resistant to other aminoglycosides like gentamicin and tobramycin

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With the global phaseout of leaded gasoline in the 1970s1990s, benzene reappeared as a gasoline additive, although strictly limited in most nations