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2.90 0.77 ml, p = 0.002

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24 The tobacco industry, which identified GHWLs as a threat as early as 1985, slowed diffusion by preventing innovations in one country from spreading to others

Moreover, these effects seem to be dose-dependent, at high concentrations of nicotine, osteoblast-like cells demonstrate decreased proliferation and impaired collagen synthesis 93 , whereas at low levels these cells are stimulated 34

Finally, people with a history of substance dependence are at higher risk for developing problematic use patterns, since nicotine acts on reward pathways that overlap with other addictions