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In a meta-analysis study comparing multiple prospective cohort studies, tobacco smoking showed a two-fold (past smokers) and a five-fold (current smokers) increased risk of abdominal aortic aneurysm compared to non-smokers

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For acute toxicity, the lethal dose is between 60 mg and 600 mg (30 cigarettes to 300 cigarettes), with toxicity resulting from stimulation of the least sensitive subtype of receptor (neuromuscular) that is present on nerves that stimulate skeletal muscle

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Tobacco can be processed, dried, rolled, and smoked as: Cigarettes