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As the sky started falling for cigarette companies in the 1970s and 80s, Big Tobacco looked abroad to sell cigarettes

doi: 10.1038/s41467-021-21602-9 60 FeiseR

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Cigarette heat and Tar The heat produced by the cigarette causes your skin to become bone dry and the tar makes your teeth and lips become yellowish in color

These results stand in contrast to a purely dopaminergic reward theory, leading to a better understanding of the neurobiology of nicotine motivation and possibly to improved therapeutic treatments for smoking cessation.