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The CMs showed chromatin fragmentation, convoluted nuclear membrane, enlarged mitochondria, and decreased phospho-AMP-activated protein kinase (pAMPK) immunoreactivity as the signs of apoptosis [114]

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In March last year three Worcestershire clinical groups advised no prescriptions for nicotine replacement therapy, bupropion or varenicline should be written for new patients from 1 April 2016, she said

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