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The subject remained largely taboo until 1954 with the British Doctors Study, and in 1964 United States Surgeon General's report

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and media campaigns to increase awareness about the dangers of exposure to second-hand smoke, change population attitudes about tobacco use, and expose the marketing tactics of the tobacco industry

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Collectively these findings in humans, animals, and cells strongly support the need to investigate the effects of ENDS aerosol exposures on asthmatic responses, with a particular focus on MMP12 involvement in a combined ENDS + HDM-induced asthma model